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The nightlife of the brain / Maiken Nedergaard.

Title: The nightlife of the brain / Maiken Nedergaard.
Author(s)/Relationship(s): Nedergaard, Maiken, author.
Publisher: [Bethesda, Md.] : [National Institutes of Health], [2015]
Related Names: National Institutes of Health (U.S.), sponsoring body.
Series: NIH Wednesday afternoon lecture
Description: 1 online resource (1 streaming video file (1 hr., 5 min.)) : color, sound.
Content Type: two-dimensional moving image
Media Type: computer
Carrier Type: online resource
Language: eng
Electronic Links:
MeSH Subjects: Sleep --physiology
Brain --physiology
Summary: (CIT): NIH Wednesday Afternoon Lecture Dr. Nedergaard and her colleagues recently described a macroscopic pathway in the central nervous system: the glymphatic system, which facilitates the clearance of interstitial waste products from neuronal metabolism. The glymphatic clearance of macromolecules is driven by cerebrospinal fluid (CSF) that flows along para-arterial spaces and through the brain parenchyma via support from astroglial aquaporin-4 water channels. The glymphatic circulation constitutes a complete anatomical pathway: para-arterial CSF exchanges with the interstitial fluid, solutes collect along para-venous spaces, and then drain into the vessels of the lymphatic system for ultimate excretion from the kidney or degradation in the liver. Because the glymphatic system is only active during sleep, it represents a novel and unexplored pathway for understanding the biological necessity for sleep.
Notes: Title from title screen.
NLM Unique ID: 101654003
Other ID Numbers: (DNLM)CIT:18844


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