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Antibodies against Ebola and Lassa : a global collaboration / Erica Ollmann...

Title: Antibodies against Ebola and Lassa : a global collaboration / Erica Ollmann Saphire.
Author(s)/Relationship(s): Saphire, Erica Ollmann, speaker.
Publisher: [Bethesda, Md.] : [National Institutes of Health], [2017]
Related Names: National Institutes of Health (U.S.), issuing body.
Series: Joseph J. Kinyoun memorial lecture
Description: 1 online resource (1 streaming video file (52 min.)) : color, sound.
Content Type: two-dimensional moving image
Media Type: computer
Carrier Type: online resource
Language: eng
Electronic Links:
MeSH Subjects: Ebolavirus --immunology
Antibodies, Viral --immunology
Lassa virus --immunology
Summary: (CIT): Dr. Saphire’s talk will explore the features of antibodies that protect against these deadly viruses and the ongoing need for scientists to collaborate in this research to establish a complete knowledge base. During the past three years, VIC researchers from dozens of labs on five continents have studied these protective antibodies. The VIC aims to fill critical knowledge gaps and provide a foundation of research that can be used to improve existing vaccines and antivirals, and to evaluate the pipeline of candidate countermeasures. Ollmann Saphire, who has served as VIC director since 2013, investigates the structural biology of both viruses and antibodies--how viruses like Ebola, Marburg and Lassa infect host cells, what the viruses" weaknesses are, and which antibody combinations might defeat them. This work has led to surprising and substantial discoveries in virology: Her team recently discovered that some viral proteins can change their 3D structures to play several different roles, allowing more information and more function to be encoded in concise viral genomes.
Notes: Closed-captioned.
NLM Unique ID: 101718800
Other ID Numbers: (DNLM)CIT:23616


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